Oroxylin A inhibits H2O2-induced oxidative stress in PC12 cells.

Research paper by Qinghe Q Han, Haiyu H Wang, Chong C Xiao, Ben-Dong BD Fu, Chong-Tao CT Du

Indexed on: 09 Nov '16Published on: 09 Nov '16Published in: Natural product research


Oroxylin A, a natural flavonoid isolated from Scutellaria baicalensis, has been reported to have anti-inflammatory and antioxidant effects. However, suppression of oxidative stress and neuroapoptosis by oroxylin A is largely uninvestigated. To investigate the protective effects of oroxylin A, PC12 cells were exposed to oroxylin A and hydrogen peroxide solutions and measured. Oroxylin A significantly reduced the levels of intracellular calcium and reactive oxygen species and increased the levels of CAT and Mn/SOD. Oroxylin A also inhibited the activation of caspase-3. These results suggest that treatment of PC12 cells with oroxylin A inhibits H2O2-induced oxidative stress.