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Operative indications for lung cancer with idiopathic pulmonary fibrosis.

Research paper by K K Kushibe, T T Kawaguchi, M M Takahama, M M Kimura, T T Tojo, S S Taniguchi

Indexed on: 21 Nov '07Published on: 21 Nov '07Published in: The Thoracic and cardiovascular surgeon



Abstract

Idiopathic pulmonary fibrosis (IPF) is well known to be associated with lung cancer. However, surgical morbidity and mortality in lung cancer patients with IPF remains unclear.The data of patients who underwent surgery for non-small cell lung cancer were retrospectively reviewed.Of the 1063 patients with lung cancer, 33 (3.1 %) had IPF. Patients with IPF had significantly higher postoperative pulmonary morbidity and mortality than those without IPF (33.3 vs. 2.0 %; 18.2 vs. 1.3 %, respectively, P < 0.0001). Patients with IPF had a significantly higher incidence of postoperative acute lung injury/acute respiratory distress syndrome (ALI/ARDS) than those without IPF (27.3 vs. 1.3 %, P < 0.0001). IPF patients with postoperative ALI/ARDS had a significantly lower preoperative %FVC than those without postoperative ALI/ARDS (74 +/- 9 vs. 103 +/- 14 %, P < 0.0001).Lung cancer patients with IPF who have a low preoperative %FVC should be carefully assessed prior to any surgical intervention.