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Omentin-1 levels in adolescents with polycystic ovarian syndrome.

Research paper by İlker Tolga İT Özgen, Şüera Ş Oruçlu, Sahabettin S Selek, Esra E Kutlu, Gülsüm G Guzel, Yaşar Y Cesur

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Pediatrics International



Abstract

Adipokines have been suggested to play an important role in pathogenesis of polycystic ovarian syndrome (PCOS). Omentin is an adipokine which is secreted essentially by visceral adipose tissue with an insulin sensitizing effect. Insulin resistance is a common feature of PCOS, therefore we aimed to investigate omentin-1 levels in adolescent girls with PCOS and its relationship with insulin resistance and androgens. A total of 41 adolescents with PCOS and age and body mass index (BMI) matched 30 obese girls without PCOS were enrolled to the study. The demographic, clinic and laboratory characteristics of groups were compared. Additionally, bivariate correlation analyses of omentin-1 with BMI standard deviation score (BMI SDS), insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), total and free testosterone were performed. In PCOS group HOMA-IR, free and total testosterone levels were higher than control group. Omentin-1was lower in PCOS patients compared to those of the controls (55.01±7.99 ng/mL vs 59.10±7.02 ng/mL p:0.027). Omentin-1 was inversely correlated with free testosterone levels (r:-0.527, p:0.030) and BMI SDS (r:-0.241, p:0.046) but it was not correlated with total testosterone, HOMA-IR, glucose, insulin and serum lipids. Omentin-1 levels were lower in adolescents with PCOS and hyperandrogenism was associated with this condition. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.