Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general.

Research paper by Marte W MW Gustavsen, Marte K MK Viken, Elisabeth G EG Celius, Tone T Berge, Inger-Lise IL Mero, Pål P Berg-Hansen, Jan H JH Aarseth, Kjell-Morten KM Myhr, Helle B HB Søndergaard, Finn F Sellebjerg, Annette B AB Oturai, Jan J Hillert, Lars L Alfredsson, Tomas T Olsson, Ingrid I Kockum, et al.

Indexed on: 20 Jul '14Published on: 20 Jul '14Published in: Journal of Neuroimmunology


Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.

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