Normal Macular Thickness in Healthy Indian Eyes Using Spectral Domain Optical Coherence Tomography.

Research paper by Tanie T Natung, Avonuo A Keditsu, Laura Amanda LA Lyngdoh, Begonia B Dkhar, Gunjan G Prakash

Indexed on: 24 Dec '15Published on: 24 Dec '15Published in: Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)


To determine macular thickness and its variation with age and sex in healthy Indian eyes using Zeiss spectral domain optical coherence tomography (SD-OCT).A prospective, cross-sectional study.Four hundred healthy adult subjects (≥18 years) underwent macular cube scanning using Zeiss SD-OCT. Macular thickness from all 9 regions of the Early Treatment Diabetic Retinopathy Study map was documented for each subject. Variations in macular thickness by age and sex were determined.The mean age of the subjects was 38.05 ± 12.13 (range, 18-78) years. The mean ages in men and women were 39.19 ± 12.16 and 37.13 ± 12.05 years, respectively (P > 0.05). The mean central subfield thickness (CST) of all subjects was 240.40 ± 18.26 μm, and mean macular thickness was 287.87 ± 18.07 μm. The mean CST in the right and left eyes were 240.40 ± 18.25 μm and 239.65 ± 17.73 μm, respectively (P = 0.55). Males were associated with greater mean CST and mean macular thickness compared with females (P < 0.05). There was an association of mean CST with sex (adjusted r = 0.095: P < 0.05) but not with age. Overall, the nasal quadrant was the thickest followed by the superior, inferior, and temporal subfields.This is the normative data for macular thickness in healthy Indian eyes using Zeiss SD-OCT. This will serve as a baseline for diagnosing and treating macular pathologies in Indian eyes because such data using Zeiss SD-OCT in Indian eyes have previously been lacking.