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Non-coding RNAs in cardiac fibrosis: emerging biomarkers and therapeutic targets.

Research paper by Zhongxiu Z Chen, Chen C Li, Ke K Lin, Huawei H Cai, Weiqiang W Ruan, Junyang J Han, Li L Rao

Indexed on: 15 Dec '17Published on: 15 Dec '17Published in: Cardiology journal



Abstract

Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. ncRNAs are involved in cell proliferation, apoptosis, differentiation, metabolism, and other physiological processes as well as the pathogenesis of diseases. Cardiac fibrosis is increasingly recognized as a common final pathway in advanced heart diseases. Many studies have shown that the occurrence and development of cardiac fibrosis is closely related to the regulation of ncRNAs. This review will highlight recent updates regarding the involvement of ncRNAs in cardiac fibrosis, and their potential as emerging biomarkers and therapeutic targets.