Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.

Research paper by Kamel A KA Metwally, Shada H SH Yaseen, El-Sayed M el-SM Lashine, Hassan M HM El-Fayomi, Mohamed E ME El-Sadek

Indexed on: 21 Oct '06Published on: 21 Oct '06Published in: European Journal of Medicinal Chemistry


Two series of 1,2,4-triazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles derived from three selected arylpropionic acids namely, ibuprofen, flurbiprofen and naproxen, were synthesized and evaluated for anti-inflammatory activity and ulcerogenic potential. All the tested compounds exhibited anti-inflammatory activity comparable to that of hydrocortisone. Compared to ibuprofen, however, all the tested compounds displayed more potent anti-inflammatory activity. Compounds tested for ulcerogenicity showed no or minimal ulcerogenic effect compared to indomethacin.