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No impact of current therapeutic strategies on disease reactivation after natalizumab discontinuation: a comparative analysis of different approaches during the first year of natalizumab discontinuation.

Research paper by M M Capobianco, A A di Sapio, M M Malentacchi, S S Malucchi, M M Matta, F F Sperli, A A Bertolotto

Indexed on: 06 Jul '14Published on: 06 Jul '14Published in: European Journal of Neurology



Abstract

Natalizumab discontinuation induces the recurrence of multiple sclerosis disease activity: currently no therapeutic approach has been found able to abolish disease reactivation.The recurrence of disease activity after natalizumab discontinuation was retrospectively evaluated in 79 patients who had been treated with immunomodulating agents, other first-line therapies, fingolimod or not treated.No differences have been found in clinical or magnetic resonance imaging recurrence of disease activity amongst the groups. Interestingly, no disease reactivation was observed only in one patient treated for 6 months with monthly pulses of cyclophosphamide.Disease modifying treatment or 'no treatment' is unable to abolish disease activity reactivation after natalizumab discontinuation.