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NIR-Triggered Exogenous Enzymes to Convert Prodrugs for Locoregional Chemo-Photothermal Therapy.

Research paper by Li L Cheng, Fengrong F Zhang, Shunhao S Wang, Xueting X Pan, Sichong S Han, Shuang S Liu, Hongyu H Wang, Junjie J Ma, Heyun H Shen, Huiyu H Liu, Qipeng Q Yuan

Indexed on: 08 Jul '19Published on: 10 Apr '19Published in: Angewandte Chemie International Edition



Abstract

Enzymes have been mostly explored to direct the conversion of the prodrugs in cancer therapy. However, non-specific distribution of endogenous enzymes seriously hinders their bioapplications. Herein, we developed a near-infrared light response locoregional chemo-photothermal therapy based on the exogenous enzyme delivery and remolded tumor microenvironment after irradiation. The catalytic efficiency of enzymes was enhanced by the hyperthermia, and the efficacy of photothermal therapy (PTT) was improved due to the inhibition of heat shock protein 90 by chemotherapeutics. The locoregional chemo-phototherapy achieved a one-time successful cure in 4T1 tumor-bearing mice model. Thus, a mutually reinforcing feedback loop exists between PTT and chemotherapy can be initiated by the irradiation, which holds a promising future in cancer therapy. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.