New polyphenolic beta-lactams with antioxidant activity.

Research paper by Gianfranco G Cainelli, Cristina C Angeloni, Rinaldo R Cervellati, Paola P Galletti, Daria D Giacomini, Silvana S Hrelia, Riccardo R Sinisi

Indexed on: 22 May '08Published on: 22 May '08Published in: Chemistry & Biodiversity


Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox( Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (=Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.