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New pharmacological profiles of loratadine: Effects on platelet aggregation and histamine release from repository cells

Research paper by A. Pistelli, M. G. Di Bello, S. Raspanti, E. Masini, P. F. Mannaioni

Indexed on: 01 Mar '93Published on: 01 Mar '93Published in: Inflammation Research



Abstract

Loratadine is endowed with antiallergic activity. It reduces both the immunological release of histamine in active anaphylaxis of isolated guinea-pig mast cells and in anti-IgE challenged human basophils as well as the non-immunological release of histamine induced by compound 48/80 and calcium ionophore A 23187 in isolated purified rat serosal mast cells. Loratadine was also found capable of directly reducing platelet aggregation induced by different agonists in a concentration-dependent fashion. It is capable of blocking the potentiation afforded by histamine on human platelet aggregation induced by thrombin, collagen and arachidonic acid. The present results suggest a broader profile for loratadine beyond its original role as a non-sedative anti-H1-antihistaminic drug.