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New isocoumarins from a cold-adapted fungal strain mucor sp. and their developmental toxicity to zebrafish embryos.

Research paper by Chun-Chi CC Feng, Guo-Dong GD Chen, Yan-Qiu YQ Zhao, Sheng-Chang SC Xin, Song S Li, Jin-Shan JS Tang, Xiao-Xia XX Li, Dan D Hu, Xing-Zhong XZ Liu, Hao H Gao

Indexed on: 22 Jul '14Published on: 22 Jul '14Published in: Chemistry & Biodiversity



Abstract

Three new isocoumarin derivatives, mucorisocoumarins A-C (1-3, resp.), together with seven known compounds, 4-10, were isolated from the cold-adapted fungal strain Mucor sp. (No. XJ07027-5). The structures of the new compounds were identified by detailed IR, MS, and 1D- and 2D-NMR analyses. It was noteworthy that compounds 1, 2, 4, and 5 were successfully resolved by chiral HPLC, indicating that 1-7 should exist as enantiomers. In an embryonic developmental toxicity assay using a zebrafish model, compound 3 produced developmental abnormalities in the zebrafish embryos. This is the first report of isocoumarins with developmental toxicity to zebrafish embryos.