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New coupling strategy for radionuclide labeling of synthetic polymers.

Research paper by Martin M Hruby, Jan J Kucka, Michaela M Novakova, Hana H Mackova, Miroslav M Vetrik

Indexed on: 17 Dec '09Published on: 17 Dec '09Published in: Applied Radiation and Isotopes



Abstract

We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.