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Netropsin inhibits the increase of intracellular Ca2+-dependent serine proteinase activity in sporulatingBacillus megaterium

Research paper by H. Kučerová, J. Chaloupka

Indexed on: 01 Feb '93Published on: 01 Feb '93Published in: Folia Microbiologica



Abstract

Netropsin suppressed the increase of intracellular proteolytic activity when added toB. megaterium incubated in a sporulation medium. The inhibited enzyme was a Ca2+-dependent serine proteinase. Sporulation and protein turnover in later sporulation phases were inhibited as well. Different concentrations of netropsin affected various aspects of protein catabolism differently.