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Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats.

Research paper by Maria Carolina MC Stipp, Iglesias de Lacerda IL Bezerra, Claudia Rita CR Corso, Francislaine A FA Dos Reis Livero, Luiz Alexandre LA Lomba, Adriana Rute Cordeiro AR Caillot, Aleksander Roberto AR Zampronio, José Ederaldo JE Queiroz-Telles, Giseli G Klassen, Edneia A S EA Ramos, Guilherme Lanzi GL Sassaki, Alexandra A Acco

Indexed on: 25 Jan '17Published on: 25 Jan '17Published in: Carbohydrate Polymers



Abstract

Polysaccharides are substances that modify the biological response to several stressors. The present study investigated the antitumor activity of the soluble fraction of polysaccharides (SFP), extracted from cabernet franc red wine, in Walker-256 tumor-bearing rats. The monosaccharide composition had a complex mixture, suggesting the presence of arabinoglactans, mannans, and pectins. Treatment with SFP (30 and 60mg/kg, oral) for 14days significantly reduced the tumor weight and volume compared with controls. Treatment with 60mg/kg SFP reduced blood monocytes and neutrophils, reduced the tumor activity of N-acetylglucosaminidase, myeloperoxidase, and nitric oxide, increased blood lymphocytes, and increased the levels of tumor necrosis factor α (TNF-α) in tumor tissue. Treatment with SFP also induced the expression of the cell necroptosis-related genes Rip1 and Rip3. The antineoplastic effect of SFP appears to be attributable to its action on the immune system by controlling the tumor microenvironment and stimulating TNF-α production, which may trigger the necroptosis pathway.