Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species.

Research paper by Atsushi A Araki, Takaaki T Kubota, Masashi M Tsuda, Yuzuru Y Mikami, Jane J Fromont, Jun'ichi J Kobayashi

Indexed on: 06 May '08Published on: 06 May '08Published in: Organic Letters


Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.