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N-Substituted α-trifluoromethyl β-nitro amines in the synthesis of fluorine-containing 1,2-diamines, amino alcohols, and β-amino acids

Research paper by V. Yu. Korotaev, A. Yu. Barkov, M. I. Kodess, I. B. Kutyashev, P. A. Slepukhin, A. Ya. Zapevalov

Indexed on: 20 Aug '10Published on: 20 Aug '10Published in: Russian Chemical Bulletin



Abstract

Reactions of 2-diazo-1,1,1-trifluoro-3-nitropropane or 1-trifluoromethyl-2-nitroethenes with amines and amino alcohols afforded N-mono- and N,N-disubstituted α-trifluoromethyl β-nitro amines, which were used to obtain a number of trifluoromethyl-containing 1,2-diamines, amino alcohols, and β-amino acids.