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Mutational analysis of SKP2 and P27 in Chinese Han women with premature ovarian failure.

Research paper by Zhiyi Z Zhao, Deying D Wei, Yulan Y Mu, Yingying Y Qin, Guangyu G Li, Linlin L Cui, Zi-Jiang ZJ Chen

Indexed on: 15 May '13Published on: 15 May '13Published in: Reproductive BioMedicine Online



Abstract

P27 and SKP2, a major regulator of P27, play a crucial role in ovarian function in mice. Both P27-deficient and SKP2-deficient female mice develop premature ovarian failure (POF). The coding regions of SKP2 and P27 were examined in 200 Chinese women with POF and 200 control volunteers. This study is the first to investigate SKP2 in POF. No plausible pathogenic mutations were detected. The results suggest that mutations in SKP2 and P27 are not common in Chinese Han women with POF.