Multifunctional nanocarriers for the treatment of periodontitis: Immuno-modulatory, antimicrobial and regenerative strategies.

Research paper by Emilio A EA Cafferata, Carla C Alvarez, Karla T KT Diaz, Miguel M Maureira, Gustavo G Monasterio, Fermín E FE González, Cristian C Covarrubias, Rolando R Vernal

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Oral Diseases


Periodontitis is an inflammatory disease, in which the host immuno-inflammatory response against the dysbiotic subgingival biofilm leads to the breakdown of periodontal tissues. Most of the available treatments seem to be effective in the short-term; nevertheless, permanent periodical controls and patient compliance compromise long-term success. Different strategies have been proposed for the modulation of the host immune response as potential therapeutic tools to take a better care of most susceptible periodontitis patients, such as drug local delivery approaches. Though, maintaining an effective drug concentration for a prolonged period of time has not been achieved yet. In this context, advanced drug delivery strategies using biodegradable nanocarriers have been proposed to avoid toxicity and frequency-related problems of treatment. The versatility of distinct nanocarriers allows the improvement of their loading and release capabilities, and could be potentially used for microbiological control, periodontal regeneration, and/or immuno-modulation. In the present review, we revise and discuss the most frequent biodegradable nanocarrier strategies proposed for the treatment of periodontitis, including polylactic-co-glycolic acid (PLGA), chitosan and silica-derived nanoparticles, and further suggest novel therapeutic strategies. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.