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Multi-analyte surface plasmon resonance biosensing.

Research paper by Jirí J Homola, Hana H Vaisocherová, Jakub J Dostálek, Marek M Piliarik

Indexed on: 04 Oct '05Published on: 04 Oct '05Published in: Methods



Abstract

Surface plasmon resonance (SPR) biosensors are affinity sensing devices exploiting a special mode of electromagnetic field-surface plasmon-polariton-to detect the binding of analyte molecules from a liquid sample to biomolecular recognition elements immobilized on the surface of the sensor. In this paper, we review advances of SPR biosensor technology towards detection systems for the simultaneous detection of multiple analytes (multi-analyte detection). In addition, we report application of a recently developed multichannel SPR sensor based on spectroscopy of surface plasmons and wavelength division multiplexing of sensing channels to multi-analyte detection.