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More Cytoplasm, More Problems.

Research paper by Predrag P Jevtić, Daniel L DL Levy

Indexed on: 10 May '17Published on: 10 May '17Published in: Developmental Cell



Abstract

In this issue of Developmental Cell, Kyogoku and Kitajima (2017) investigate the effect of cytoplasmic volume on the fidelity of chromosome segregation during meiosis in mouse oocytes. The authors find that large cytoplasmic volume affects spindle pole morphology, chromosome alignment, and stringency of checkpoint signaling, resulting in error-prone chromosome segregation.