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Model systems for analysis of dopamine transporter function and regulation.

Research paper by Moriah J MJ Hovde, Garret H GH Larson, Roxanne A RA Vaughan, James D JD Foster

Indexed on: 05 Sep '18Published on: 05 Sep '18Published in: Neurochemistry International



Abstract

The dopamine transporter (DAT) plays a critical role in dopamine (DA) homeostasis by clearing transmitter from the extraneuronal space after vesicular release. DAT serves as a site of action for a variety of addictive and therapeutic reuptake inhibitors, and transport dysfunction is associated with transmitter imbalances in disorders such as schizophrenia, attention deficit hyperactive disorder, bipolar disorder, and Parkinson disease. In this review, we describe some of the model systems that have been used for in vitro analyses of DAT structure, function and regulation, and discuss a potential relationship between transporter kinetic values and membrane cholesterol. Copyright © 2018. Published by Elsevier Ltd.