Möbius syndrome associated with obesity and precocious puberty.

Research paper by Samantha Roshani SR De Silva, Sally L SL Painter, Darius D Hildebrand

Indexed on: 21 Dec '18Published on: 21 Dec '18Published in: BMJ case reports


Möbius syndrome is a neurological disorder involving underdevelopment of the sixth and seventh cranial nerves. Multiple associations have been described including dysfunction of other cranial nerves, limb abnormalities and hypogonadotrophic hypogonadism causing delayed puberty. We present the second reported case of Möbius syndrome associated with obesity and with precocious puberty. These features may be secondary to dysregulation of the hypothalamic-pituitary axis. We highlight the need to consider extraocular symptoms in these patients and for close liaison with physicians in their management. © BMJ Publishing Group Limited 2018. No commercial re-use. See rights and permissions. Published by BMJ.