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Mobility and cognition: End points for dietary interventions in aging

Research paper by Marshall G. Miller, Tufts University, Medford, MA, USA<br>Derek A. Hamilton, University of New Mexico, Albuquerque, NM, USA<br>James A. Joseph, Tufts University, Medford, MA, USA<br>Barbara Shukitt-;Hale, United States Department of Agriculture -; Agricultural Research Services, Human Nutrition Research Center on Aging, et al.

Indexed on: 14 May '16Published on: 26 Aug '14Published in: Nutrition and aging (Amsterdam, Netherlands)



Abstract

BACKGROUND: Healthy aging is associated with functional declines in mobility and cognition among both humans and non-human animals. OBJECTIVE: This study combines human measures of mobility and cognition to develop a test battery for evaluating the effects of dietary supplements among older adults. Selected measures parallel behavior tasks used to assess the efficacy of dietary interventions in rodent models of aging. METHODS: Seventy six healthy adults, between the ages of 21 and 75, completed a 1 hour mobility and cognition assessment. Postural sway and spatiotemporal gait parameters were measured using a Zebris™ instrumented treadmill system. A computer-based virtual water maze and the trail-making test were used to assess spatial memory and executive function, respectively. RESULTS: Sway velocity during quiet standing increased with age. Preferred gait speed declined with age and changes in the gait cycle reveal an age-related increase in total double support during normal walking. In the virtual water maze, latency to locate a hidden or visible platform increased with age; meanwhile, probe test performance declined with age. CONCLUSIONS: Healthy adults show age-related declines in measures of mobility and cognition. These measures are a useful tool for translating research on dietary interventions to older adults. Content Type Journal ArticlePages 213-222DOI 10.3233/NUA-140046Authors Marshall G. Miller, Tufts University, Medford, MA, USADerek A. Hamilton, University of New Mexico, Albuquerque, NM, USAJames A. Joseph, Tufts University, Medford, MA, USABarbara Shukitt-Hale, United States Department of Agriculture - Agricultural Research Services, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA Journal Nutrition and AgingOnline ISSN 1879-7725Print ISSN 1879-7717 Journal Volume Volume 2 Journal Issue Volume 2, Number 4 / 2014 BACKGROUND: Healthy aging is associated with functional declines in mobility and cognition among both humans and non-human animals. OBJECTIVE: This study combines human measures of mobility and cognition to develop a test battery for evaluating the effects of dietary supplements among older adults. Selected measures parallel behavior tasks used to assess the efficacy of dietary interventions in rodent models of aging. METHODS: Seventy six healthy adults, between the ages of 21 and 75, completed a 1 hour mobility and cognition assessment. Postural sway and spatiotemporal gait parameters were measured using a Zebris™ instrumented treadmill system. A computer-based virtual water maze and the trail-making test were used to assess spatial memory and executive function, respectively. RESULTS: Sway velocity during quiet standing increased with age. Preferred gait speed declined with age and changes in the gait cycle reveal an age-related increase in total double support during normal walking. In the virtual water maze, latency to locate a hidden or visible platform increased with age; meanwhile, probe test performance declined with age. CONCLUSIONS: Healthy adults show age-related declines in measures of mobility and cognition. These measures are a useful tool for translating research on dietary interventions to older adults. Content Type Journal ArticlePages 213-222DOI 10.3233/NUA-140046Authors Marshall G. Miller, Tufts University, Medford, MA, USADerek A. Hamilton, University of New Mexico, Albuquerque, NM, USAJames A. Joseph, Tufts University, Medford, MA, USABarbara Shukitt-Hale, United States Department of Agriculture - Agricultural Research Services, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA Content Type Journal ArticleContent Type Journal ArticlePages 213-222DOI 10.3233/NUA-140046Authors Marshall G. Miller, Tufts University, Medford, MA, USADerek A. Hamilton, University of New Mexico, Albuquerque, NM, USAJames A. Joseph, Tufts University, Medford, MA, USABarbara Shukitt-Hale, United States Department of Agriculture - Agricultural Research Services, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA Authors Marshall G. Miller, Tufts University, Medford, MA, USADerek A. Hamilton, University of New Mexico, Albuquerque, NM, USAJames A. Joseph, Tufts University, Medford, MA, USABarbara Shukitt-Hale, United States Department of Agriculture - Agricultural Research Services, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA Marshall G. Miller, Tufts University, Medford, MA, USADerek A. Hamilton, University of New Mexico, Albuquerque, NM, USAJames A. Joseph, Tufts University, Medford, MA, USABarbara Shukitt-Hale, United States Department of Agriculture - Agricultural Research Services, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA Journal Nutrition and AgingOnline ISSN 1879-7725Print ISSN 1879-7717 Journal Volume Volume 2 Journal Issue Volume 2, Number 4 / 2014 Journal Nutrition and AgingOnline ISSN 1879-7725Print ISSN 1879-7717 Journal Nutrition and AgingJournal Nutrition and AgingNutrition and AgingOnline ISSN 1879-7725Online ISSN 1879-7725Print ISSN 1879-7717Print ISSN 1879-7717 Journal Volume Volume 2 Journal Volume Volume 2Journal Volume Volume 2 Journal Issue Volume 2, Number 4 / 2014 Journal Issue Volume 2, Number 4 / 2014Journal Issue Volume 2, Number 4 / 2014Volume 2, Number 4 / 2014