Mitochondrial toxicity associated with HAART following liver transplantation in an HIV-infected recipient.

Research paper by Charalambos C Antoniades, Candice C Macdonald, Alexander A Knisely, Christopher C Taylor, Suzanne S Norris

Indexed on: 27 Apr '04Published on: 27 Apr '04Published in: Liver Transplantation


Antiretroviral therapy is not uncommonly associated with drug toxicities, and hepatotoxicity occurs in approximately 20% of individuals prescribed antiretroviral therapy. Mitochondrial toxicity causing lactic acidosis is a rare but fatal complication that has been described in some HIV-infected patients treated with nucleoside analogue reverse transcriptase inhibitors. In this report, we describe the course of an HIV-infected patient receiving antiretroviral therapy who developed lactic acidosis after liver transplantation for HCV-induced liver disease.