Indexed on: 21 Jun '17Published on: 21 Jun '17Published in: Journal of Allergy and Clinical Immunology
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by interferon-γ treatment.
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