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Mitochondrial DNA depletion induces innate immune dysfunction rescued by interferon-γ.

Research paper by John D JD Widdrington, Aurora A Gomez-Duran, Jannetta S JS Steyn, Angela A Pyle, Marie-Helene MH Ruchaud-Sparagano, Jonathan J Scott, Simon V SV Baudouin, Anthony J AJ Rostron, John J Simpson, Patrick F PF Chinnery FMedSci

Indexed on: 21 Jun '17Published on: 21 Jun '17Published in: Journal of Allergy and Clinical Immunology



Abstract

Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by interferon-γ treatment.