Indexed on: 14 Apr '15Published on: 14 Apr '15Published in: Cell and Tissue Biology
It is shown that mitochondria-targeted antioxidant SkQR1 protects erythroleukemia K562 cells from radiation injury. Pretreatment with SkQR1 before irradiation decreased generation of DNA double-strand breaks, diminished the number of chromosomal aberrations, and suppressed delayed ROS production. Prevention of oxidative stress and normalization of mitochondrial function by mitochondria-targeted antioxidants may be a potential therapeutic strategy not only against the immediate consequences of radiation, but also against its late consequences, such as genomic instability. SkQR1 did not protect against radiation-induced damage of K562 cells with a high level of multidrug resistance (MDR) due to SkQR1 extrusion with a Pgp170 MDR pump. We suggest that mitochondria-targeted antioxidants can be used for selective protection of normal cells against radiation-induced damage without interference with radiotherapy of MDR-positive tumors.