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Mitochondria-targeted antioxidant SkQR1 selectively protects MDR-negative cells from ionizing radiation

Research paper by E. K. Fetisova, M. M. Antoschina, V. D. Cherepanynets, D. S. Izumov, I. I. Kireev, R. I. Kireev, K. G. Lyamzaev, N. I. Riabchenko, B. V. Chernyak, V. P. Skulachev

Indexed on: 14 Apr '15Published on: 14 Apr '15Published in: Cell and Tissue Biology



Abstract

It is shown that mitochondria-targeted antioxidant SkQR1 protects erythroleukemia K562 cells from radiation injury. Pretreatment with SkQR1 before irradiation decreased generation of DNA double-strand breaks, diminished the number of chromosomal aberrations, and suppressed delayed ROS production. Prevention of oxidative stress and normalization of mitochondrial function by mitochondria-targeted antioxidants may be a potential therapeutic strategy not only against the immediate consequences of radiation, but also against its late consequences, such as genomic instability. SkQR1 did not protect against radiation-induced damage of K562 cells with a high level of multidrug resistance (MDR) due to SkQR1 extrusion with a Pgp170 MDR pump. We suggest that mitochondria-targeted antioxidants can be used for selective protection of normal cells against radiation-induced damage without interference with radiotherapy of MDR-positive tumors.