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miR-146a inhibits biofilm-derived Cutibacterium acnes induced inflammatory reactions in human keratinocytes

Research paper by Rong Zeng, Haoxiang Xu, Yuzhen Liu, Leilei Du, Zhimin Duan, Jianbo Tong, Yanyan He, Qing Chen, Xu Chen, Min Li

Indexed on: 11 Feb '20Published on: 10 Jun '19Published in: Journal of Investigative Dermatology



Abstract

Acne is a chronic inflammatory skin disorder that often involves the formation of C. acnes biofilms. Several microRNAs (miRNAs) are known to be involved in inflammatory responses. However, it is unknown whether miRNAs play a role in the inflammatory reaction triggered by C. acnes biofilm. Here we investigated the role of miR-146a in biofilm-derived C. acnes induced inflammatory responses. Increased expressions of miR-146a and toll-like receptor (TLR) 2 were detected in acne lesions. In presence of biofilm-derived C.