Quantcast

miR-135a inhibits tumor metastasis and angiogenesis by targeting FAK pathway.

Research paper by Zhenguo Z Cheng, Funan F Liu, Hongyan H Zhang, Xiaodong X Li, Yanshu Y Li, Jiabin J Li, Furong F Liu, Yu Y Cao, Liu L Cao, Feng F Li

Indexed on: 19 Apr '17Published on: 19 Apr '17Published in: Oncotarget



Abstract

Tumor metastasis has been the major cause of recurrence and death in patients with gastric cancer. Here, we find miR-135a has a decreased expression in the metastatic cell lines compared with its parental cell lines by analyzing microRNA array. Further results show that miR-135a is downregulated in the majority of human gastric cancer tissues and cell lines. Decreased expression of miR-135a is associated with TNM stage and poor survival. Besides, regaining miR-135a in gastric cancer cells obviously inhibits tumor growth, migration, invasion and angiogenesis by targeting focal adhesion kinase (FAK) pathway. Bioinformatics analysis and molecular experiments further prove that miR-135a is a novel downstream gene of tumor suppressor p53. Blocking FAK with its inhibitor can also enhance miR-135a expression through inducing p53. In summary, this study reveals the expression and function of miR-135a in gastric cancer and uncovers a novel regulatory mechanism of miR-135a.