Minor increase of endtidal CO2 during sevoflurane-induced malignant hyperthermia.

Research paper by Monalisa M Bonciu, Arnaud A de la Chapelle, Henry H Delpech, Thiery T Depret, Reneé R Krivosic-Horber, Marc Raucoules MR Aimé

Indexed on: 24 Jan '07Published on: 24 Jan '07Published in: Pediatric Anesthesia


Malignant hyperthermia (MH) in a pediatric patient during sevoflurane anesthesia with only a minor rise of endtidal CO(2) is described. MH was considered because of increased rectal temperature. The outcome was favorable after the initiation of a few simple measures (increased minute ventilation, cessation of sevoflurane). As recommended by the regional MH Reference Center, dantrolene was not used. In vitro contracture tests were performed on muscle biopsies from both parents. A strong contracture in response to halothane confirmed the father's MH susceptibility, thereby according a high probability of an MH episode in his son.