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Methamphetamine downregulates peroxiredoxins in rat pheochromocytoma cells.

Research paper by Han-Min HM Chen, Yi-Chao YC Lee, Chuen-Lin CL Huang, Hui-Kang HK Liu, Wei-Chen WC Liao, Wen-Lin WL Lai, Yen-Ru YR Lin, Nai-Kuei NK Huang

Indexed on: 11 Jan '07Published on: 11 Jan '07Published in: Biochemical and Biophysical Research Communications



Abstract

Methamphetamine (METH) is an abusive psychostimulant that induces neuronal cell death/degeneration in experimental animals and humans. METH-induced apoptosis in rat pheochromocytoma cells was utilized to study the neurotoxic mechanism. During METH intoxication, we found that peroxiredoxins and thioredoxins/thioredoxin reductases (peroxiredoxin reducing systems) which are known to prevent oxidative stress and apoptosis were differentially downregulated and upregulated, respectively. We also found not only the free radicals but also the oxidative forms of peroxiredoxin and thioredoxin were increased, indicating the dysfunction of these enzymes. Thus, METH-induced differential regulation and oxidation of peroxiredoxins and thioredoxin may be an important mechanism for apoptosis.