Masticatory deficiency as a risk factor for cognitive dysfunction.

Research paper by Francisco Bruno FB Teixeira, Luanna de Melo Lde M Pereira Fernandes, Patrycy Assis Tavares PA Noronha, Marcio Antonio Raiol MA dos Santos, Walace W Gomes-Leal, Cristiane do Socorro Cdo S Ferraz Maia, Rafael Rodrigues RR Lima

Indexed on: 28 Jan '14Published on: 28 Jan '14Published in: International journal of medical sciences


Several studies have demonstrated that chewing helps to maintain cognitive functions in brain regions including the hippocampus, a central nervous system (CNS) region vital for memory and learning. Epidemiological studies suggest that masticatory deficiency is associated with development of dementia, which is related to spatial memory deficits especially in older animals. The purpose of this paper is to review recent work on the effects of masticatory impairment on cognitive functions both in experimental animals and humans. We show that several mechanisms may be involved in the cognitive deficits associated with masticatory deficiency. The epidemiological data suggest a positive correlation between masticatory deficit and Alzheimer's disease. It may be concluded that chewing has important implications for the mechanisms underlying certain cognitive abilities.