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Massive transfusion of blood in the surgical patient.

Research paper by Jordan M JM Raymer, Lisa M LM Flynn, Ronald F RF Martin

Indexed on: 15 Mar '12Published on: 15 Mar '12Published in: Surgical Clinics of North America



Abstract

Hemorrhage remains a leading cause of morbidity and death in both civilian and military trauma. Restoration of effective end-organ perfusion by stopping hemorrhage and restoring intravascular volume in such a way as to minimize acidosis, hypothermia, and coagulopathy, almost always requires the use of blood and/or blood-component therapy. The best method to manage life-threatening hemorrhage is to avoid the circumstance that prompted it or to mitigate blood loss early in the injury cycle; otherwise, blood replacement must suffice. This article reviews current understanding of massive transfusion, along with its attendant unintended consequences, in the management of patients with profound hemorrhage.