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Magnesiation of electron-rich aryl bromides and their use in nickel-catalyzed cross-coupling reactions.

Research paper by Stephen Y W SY Lau, Greg G Hughes, Paul D PD O'Shea, Ian W IW Davies

Indexed on: 08 May '07Published on: 08 May '07Published in: Organic Letters



Abstract

Electron-rich aryl bromides are rapidly converted to the corresponding lithium triarylmagnesiates with (n-Bu)3MgLi, which undergo efficient nickel-catalyzed Kumada-Corriu cross-coupling reactions with a variety of aryl and alkenyl bromides, chlorides, tosylates, and triflates.