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Luteal estrogen supplementation in stimulated cycles may improve the pregnancy rate in patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer.

Research paper by Peter P Drakakis, Dimitris D Loutradis, Eleftheria E Vomvolaki, Konstantinos K Stefanidis, Erasmia E Kiapekou, Elli E Anagnostou, Kiki K Anastasiadou, Spiros S Milingos, Aris A Antsaklis

Indexed on: 14 Nov '07Published on: 14 Nov '07Published in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology



Abstract

To evaluate the effect of estradiol addition to progesterone supplementation during the luteal phase on pregnancy and implantation rates in patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles.In this prospective, randomized study, carried out in an IVF unit of a university hospital, we studied patients who were undergoing IVF/ICSI with controlled ovarian hyperstimulation using a gonadotropin-releasing hormone agonist/human recombinant gonadotropin long protocol. The main outcome measures were the pregnancy and implantation rates measured in the two groups.Our results suggest higher pregnancy and implantation rates in IVF/ICSI-ET cycles that were supplemented with estradiol in the luteal phase.Estradiol supplementation during the luteal phase in women undergoing IVF/ICSI-ET has a beneficial effect on the outcome without (at least, as seems from this study) having any adverse effects.