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Loosening pain's grip by tightening TRPV1-TRPA1 interactions.

Research paper by Andy D AD Weyer, Cheryl L CL Stucky

Indexed on: 20 Feb '15Published on: 20 Feb '15Published in: Neuron



Abstract

TRPA1 and TRPV1 are ion channels crucial for pain sensation. In this issue of Neuron, Weng et al. (2015) demonstrate that the activity of TRPA1-TRPV1 heteromers is governed by Tmem100 and that disabling Tmem100 may be a novel pharmacologic strategy to combat pain.