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Long-term thiol monitoring in living cells using bioorthogonal chemistry.

Research paper by Lei L Rong, Chi C Zhang, Qi Q Lei, Hua-Ling HL Sun, Si-Yong SY Qin, Jun J Feng, Xian-Zheng XZ Zhang

Indexed on: 20 Nov '14Published on: 20 Nov '14Published in: Chemical Communications



Abstract

Intracellular thiols play vital roles in living systems, and their in situ monitoring is of great importance. Here, we report on a bioorthogonal chemistry based fluorescent probe, which is capable of monitoring intracellular thiols in living cells for up to 36 hours with an obvious blue-to-green fluorescence change.