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Long-Term Release of Antibiotics by Carbon Nanotube-Coated Titanium Alloy Surfaces Diminish Biofilm Formation by Staphylococcus epidermidis.

Research paper by Josefine J Hirschfeld, Eser M EM Akinoglu, Dieter C DC Wirtz, Achim A Hoerauf, Isabelle I Bekeredjian-Ding, Søren S Jepsen, El-Mustapha EM Haddouti, Andreas A Limmer, Michael M Giersig

Indexed on: 25 Jan '17Published on: 25 Jan '17Published in: Nanomedicine: Nanotechnology, Biology and Medicine



Abstract

Bacterial biofilms cause a considerable amount of prosthetic joint infections every year, resulting in morbidity and expensive revision surgery. To address this problem, surface modifications of implant materials such as carbon nanotube (CNT) coatings have been investigated in the past years. CNTs are biologically compatible and can be utilized as drug delivery systems. In this study, multi-walled carbon nanotube (MWCNT) coated TiAl6V4 titanium alloy discs were fabricated and impregnated with Rifampicin, and tested for their ability to prevent biofilm formation over a period of ten days. Agar plate-based assays were employed to assess the antimicrobial activity of these sufaces against Staphylococcus epidermidis. It was shown that vertically aligned MWCNTs were more stable against attrition on rough surfaces than on polished TiAl6V4 surfaces. Discs with coated surfaces caused a significant inhibition of biofilm formation for up to five days. Therefore, MWCNT-modified surfaces may be effective against pathogenic biofilm formation on endoprostheses.