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Liquid pharmaceutical for oral delivery

Imported: 24 Feb '17 | Published: 09 Sep '03

Suggy S. Chrai, Ramaswamy Murari

USPTO - Utility Patents

Abstract

A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a plan schematic view of a system for making a product according to one embodiment of the present invention;

FIG. 2 is a schematic side elevation sectional view of a robotically operated electrostatic chuck for carrying a substrate forming the unit forms of an embodiment of the present invention;

FIG. 3 is a side elevation sectional view of the chuck of FIG. 2 taken along lines

2

2;

FIG. 4 is a plan view of a gasket employed in the embodiment of FIGS. 2 and 3;

FIG. 5 is a side elevation sectional schematic view of the formation of a package of the present invention at a lamination station;

FIG. 6 is a plan view of a front surface the electrostatic chuck of FIG. 2 without the gasket in place showing the surface of the chuck showing through holes and collection zones for active powder/grains;

FIG. 7 is a plan view of a rear surface of the chuck of FIG. 6 showing addressing electrodes coupled to drive electronics (not shown) for driving powder collection electrodes;

FIG. 8 is a plan view of the underside of the chuck attached to a robotically operated receiving head;

FIG. 9 is a plan view of the receiving head without the chuck installed;

FIGS. 10

a,

10

b and

10

c are schematic sectional elevation views of different embodiments of powder/grain attracting electrodes that may be employed in the electrostatic chuck embodiment of FIGS. 2,

3,

6,

7 and

8;

FIG. 11A is a schematic illustration of a diffuse reflection system for characterizing the amount of deposited dry powders;

FIG. 11B is a schematic illustration of an optical profilometry system for characterizing the amount of deposited dry powder/grains;

FIG. 12 illustrates a substrate that can be measured with both the optical profilometry and diffusion reflection systems of FIGS. 11B and 11A respectively;

FIG. 13 is a graph useful for explaining the principles of the present invention;

FIG. 14 is schematic plan view of a detection array at the measurement station of the embodiment of FIG. 1;

FIG. 15 is a schematic circuit diagram for providing an AC bias charge and deposition sensing for a floating pad electrode;

FIG. 16 is a waveform diagram useful for explaining the principles of the diagram of FIG. 15; and

FIG. 17 is a schematic circuit diagram for providing an alternative AC bias charge and deposition sensing.

Claims

1. A process for administering a pharmaceutical in a pharmaceutically acceptable liquid carrier, comprising:

2. The process of claim 1 wherein said pharmaceutically acceptable liquid carrier is water.

3. The process of claim 1 wherein said substrate is comprised of at least one material selected from the group consisting of gelatin, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, sodium alginate, carboxymethylcellulose, and agar.

4. The process of claim 1 wherein said at least one pharmaceutically active material is an antibiotic.

5. The process of claim 1 wherein said pharmaceutically active material is an anti-viral agent.

6. The process of claim 1 wherein said pharmaceutically active material is an anti-fungal agent.

7. The process of claim 1 wherein said at least one pharmaceutically active material is an anti-infective agent.