Indexed on: 25 Jan '17Published on: 25 Jan '17Published in: Pediatrics International
Some very-low-birth-weight (VLBW) infants develop refractory hypotension, which is resistant to intravenous volume expanders and inotropes, but responds to exogenous glucocorticoid dramatically.(1-8) Such refractory hypotension usually occurs just after birth or within the early neonatal period (<Day 7). However, cases of refractory hypotension after the early neonatal period (>Day 7) have been reported since 2000 in Japan.(9) In typical cases, infants are stabilized for a period within the early neonatal period, and the sudden onset of circulatory collapse then subsequently occurs.(10) The synchrony of such dramatic clinical courses suggested a new entity of late-onset circulatory collapse (LCC), which differed from the previous known early refractory hypotension.(11).