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Lamivudine resistance of hepatitis B virus masked by coemergence of mutations in probe region of the COBAS AMPLICOR assay.

Research paper by Magnus M Lindh, Charles C Hannoun, Sebastian S Malmström, Johan J Lindberg, Gunnar G Norkrans

Indexed on: 11 Jul '06Published on: 11 Jul '06Published in: Journal of clinical microbiology



Abstract

The COBAS AMPLICOR hepatitis B virus assay targets a conserved region of the genome and is widely used to monitor treatment of hepatitis B in order to identify emerging resistance. However, the assay failed to recognize increasing viremia levels when YMDD mutations were paralleled by mutations in the segment targeted by the COBAS AMPLICOR probe.