Krüppel-like factors: Crippling and un-crippling metabolic pathways.

Research paper by Nina M NM Pollak, Matthew M Hoffman, Ira J IJ Goldberg, Konstantinos K Drosatos

Indexed on: 08 Jun '18Published on: 08 Jun '18Published in: JACC. Basic to translational science


Krüppel-like factors (KLFs) are DNA-binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. In this review article we summarize the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease.