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Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica.

Research paper by Lin L Chen, Jia-Luo JL Huang, Lei L Zhang, Hai-Yan HY Tian, Sheng S Yin

Indexed on: 28 Oct '19Published on: 12 May '19Published in: Chinese Journal of Natural Medicines



Abstract

Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2-9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC of 13.44 ± 0.28 μmol·L, being comparable to the positive control, quercetin (IC 17.00 ± 2.10 μmol·L). Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.