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Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium Lyngbya sp.

Research paper by Arihiro A Iwasaki, Osamu O Ohno, Shinpei S Sumimoto, Hidetoshi H Ogawa, Kim Anh KA Nguyen, Kiyotake K Suenaga

Indexed on: 15 Jan '15Published on: 15 Jan '15Published in: Organic Letters



Abstract

An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.