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Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa.

Research paper by Sachiko S Tsukamoto, Kyoko K Tomise, Maki M Aburatani, Hiroyuki H Onuki, Hiroshi H Hirorta, Eiji E Ishiharajima, Tomihisa T Ohta

Indexed on: 01 Dec '04Published on: 01 Dec '04Published in: Journal of Natural Products



Abstract

A new glycoside, 2-beta-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-beta-D-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metabolizing enzyme, CYP3A4.