Iron(III) chloride hexahydrate-promoted selective hydroxylation and chlorination of benzyl ketone derivatives for the construction of hetero-quaternary scaffolds

Research paper by Tao Chen, Rui Peng, Wenxin Hu, Fu-Min Zhang

Indexed on: 14 Oct '16Published on: 21 Sep '16Published in: Organic & Biomolecular Chemistry


A novel and tunable α-hydroxylation/α-chlorination of benzyl ketone derivatives has been developed for the construction of hetero-quaternary carbon centers by iron(III) chloride hexahydrate mediated selective transformations through the application of different oxidants, especially the crystal water in the catalyst as an OH source is firstly reported in this hydroxylation.

Graphical abstract 10.1039/C6OB01733A.gif