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Iron-catalyzed 1,2-addition of perfluoroalkyl iodides to alkynes and alkenes.

Research paper by Tao T Xu, Chi Wai CW Cheung, Xile X Hu

Indexed on: 01 Apr '14Published on: 01 Apr '14Published in: Angewandte Chemie International Edition



Abstract

Iron catalysis has been developed for the intermolecular 1,2-addition of perfluoroalkyl iodides to alkynes and alkenes. The catalysis has a wide substrate scope and high functional-group tolerance. A variety of perfluoroalkyl iodides including CF3 I can be employed. The resulting perfluoroalkylated alkyl and alkenyl iodides can be further functionalized by cross-coupling reactions. This methodology provides a straightforward and streamlined access to perfluoroalkylated organic molecules.