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Investigation of maternal and cord blood erythropoietin and copeptin levels in low-risk term deliveries complicated by meconium stained amniotic fluid.

Research paper by Hakan H Timur, Aytekin A Tokmak, Selen S Taflan, Necati N Hançerlioğulları, Bergen B Laleli, Özlem Ö Moraloğlu, Nuri N Danışman

Indexed on: 29 Apr '16Published on: 29 Apr '16Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians



Abstract

To compare maternal, cord blood erythropoietin (EPO) and copeptin levels in low risk term deliveries which are complicated by meconium stained amniotic fluid (MSAF) to those with clear amniotic fluid. Also to evaluate the relations between these markers and cord blood pH values.Low-risk term pregnant women with MSAF at an active phase of labor were defined as the study group (n = 39). Pregnant women with clear amniotic fluid were matched for age and body mass index while gestational age were defined as the control group (n = 41). Maternal, cord blood EPO and copeptin levels with cord blood pH values were also measured.Maternal, cord blood EPO and copeptin levels of study and control groups were 42.6±9.0 vs. 40.7±9.2, 134.2(20.5-834.6) vs. 38.4(10.3-114.2), 4.9(0.1-31.1) vs. 4.0(3.1-28.4), and 4.7(2.6-25.5) vs. 3.6(2.0-23.2), respectively. The differences were statistically significant for cord blood EPO, maternal and cord blood copeptin levels (p < 0.001, p = 0.004, p < 0.001, respectively). The study group had a statistically and significantly lower cord blood pH values (7.25±0.05 vs. 7.34±0.04, p < 0.001). Moreover, cord blood EPO and maternal and cord blood copeptin levels were inversely correlated with cord blood pH values in the study group (p < 0.001, p = 0.005, and p = 0.009, respectively).We suggest that higher cord blood erythropoietin and maternal and cord blood copeptin levels may be an indicator of fetal acidosis in low-risk term deliveries complicated by MSAF.

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