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Investigation of cystatin C and cystatin C based estimated glomerular filtration rate in pregnant patients with heart failure.

Research paper by Mengyan M Xu, Zhidong Z Guo, Qiqi Q Wang, Jianmei J Jin, Tao T Wu, Yuangang Y Qiu

Indexed on: 19 Jun '12Published on: 19 Jun '12Published in: Clinical chemistry and laboratory medicine



Abstract

Impaired cardiac function leads to impaired renal function. We assessed renal function in pregnant patients with heart failure.This was a retrospective study. From 1999 to 2010, 42 pregnant patients with heart failure were classified into the single-pregnancy group and the twin or multifetation group. Clinical manifestations were assessed. Serum concentrations of creatinine and cystatin C were assessed. Estimated glomerular filtration rate (eGFR) based on serum concentrations of creatinine or cystatin C was completed.There were 29 single pregnancies, 12 twin pregnancies, and one multifetation. Ten patients in the twin pregnancy or multifetation group had in-vitro fertilization. The concentration of creatinine was 84.6±33.8 μmol/L and the creatinine-based eGFR was 87.2±34.9 mL/min per 1.73 m2. The percentage of patients with a creatinine based eGFR<60 mL/min per 1.73 m2was 23.8%. The concentration of cystatin C was 1.5±0.7 mg/L and the cystatin C-based eGFR was 65.2±45.8 mL/min per 1.73 m2. The percentage of patients with a cystatin C-based eGFR<60 mL/min per 1.73 m2was 52.4%.Serum concentrations of cystatin C and cystatin C-based eGFR are important indicators of renal impairment in pregnant patients with heart failure.