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Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I 2 : synthesis of [2,3]-fused indoline tetrahydropyridazines

Research paper by Wei Feng, Liang Cheng; Hongyan Huang; Jiejie Liu; Dong Wang; Li Liu

Indexed on: 01 Sep '16Published on: 22 Aug '16Published in: Science China. Chemistry



Abstract

Abstract A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide (TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.AbstractA convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide (TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.2tert